【基本情况】

徐志刚，第一临床医学院耳鼻咽喉头颈外科兼职教授，学术型博士研究生导师。

【学习经历】

1995.09—1998.07  烟台大学化学生物理工学院生物化学专业，学士

1998.09—2004.01  复旦大学生命科学学院遗传学专业，博士

【工作经历】

2004.12— 2005.09  哈佛大学医学院，博士后

2005.10— 2009.05  斯坦福大学医学院，博士后

2009.05— 至今     山东大学生命科学学院，教授

2024.12— 至今     兰州大学第一临床医学院，兼职教授

【主要科研成果】

研究方向：听觉转导及耳聋发生机制

发表主要论文或专著：

• Yao X, Zhang Y, Hong X, Xing Y, Xu Z*. Esrp1 and Esrp2 regulate the stability of tmc1/2a mRNAs in zebrafish sensory hair cells. J Neurosci. 2025; 45 (17): e0837242025.
• Wu S, Lin L, Hu Q, Yao X, Wang H, Liu S, Liu Q, Xi Y, Lin Y, Gong J, Hu R, Zhan W, Luo Y, He G, Liu Z, Xiong W, Wang Q*, Xu Z*, Bai F*, Lu Q*. Mechano-electrical transduction components TMC1-CIB2 undergo a Ca(2+)-induced conformational change linked to hearing loss. Dev Cell. 2025; 60(11):1586-1600.
• Li N, Liu S, Zhao D, Du H, Xi Y, Wei X, Liu Q, Müller U, Lu Q*, Xiong W*, Xu Z*. Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip-link stability. Proc Natl Acad Sci U S A. 2024; 121(10):e2309656121.
• Yan K, Zhang H, Qu C, Xi Y, Han ZG, Xu Z*. BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology. FASEB J. 2024; 38(15):e23860.
• Zhu GJ, Huang Y, Zhang L, Yan K, Qiu C, He Y, Liu Q, Zhu C, Morín M, Moreno-Pelayo MÁ, Zhu MS, Cao X, Zhou H, Qian X, Xu Z*, Chen J*, Gao X*, Wan G*. Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse. EMBO Mol Med. 2023; 15(11):e17611.
• Guan Y, Du HB, Yang Z, Wang YZ, Ren R, Liu WW, Zhang C, Zhang JH, An WT, Li NN, Zeng XX, Li J, Sun YX, Wang YF, Yang F, Yang J, Xiong W, Yu X, Chai RJ, Tu XM*, Sun JP*, Xu ZG*. Deafness-associated ADGRV1 mutation impairs USH2A stability through improper phosphorylation of WHRN and WDSUB1 recruitment. Adv Sci (Weinh). 2023; 10(16):e2205993.
• Wang X, Liu S, Cheng Q, Qu C, Ren R, Du H, Li N, Yan K, Wang Y, Xiong W*, Xu Z*. CIB2 and CIB3 regulate stereocilia maintenance and mechanoelectrical transduction in mouse vestibular hair cells. J Neurosci. 2023; 43(18):3219-3231.
• Ren R, Xing H, Wang X, Du H, Wang Y, Xu Z*. Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death. Hum Mol Genet. 2023; 32(10):1622-1633.
• Wang H, Du H, Ren R, Du T, Lin L, Feng Z, Zhao D, Wei X, Zhai X, Wang H, Dong T, Sun JP, Wu H, Xu Z^*, Lu Q^*. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation. Nat Commun. 2023; 14(1):1657.
• Zhai X, Du H, Shen Y, Zhang X, Chen Z, Wang Y, Xu Z^*. FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells. J Cell Sci. 2022; 135(16):jcs259912.