【基本情况】

接英，主任医师/教授，首都医科大学附属北京同仁医院学术学位博士研究生导师（眼科学）/专业学位博士研究生导师（眼科学）。

【学习经历】

1994-9至1999-8, 泰山医学院，学士

1999-9至2002-8, 首都医科大学，硕士

2002-9至2005-8, 首都医科大学，博士

【工作经历】

2006-08至2010-12, 首都医科大学, 北京同仁医院, 主治医师

2011-01至2016-10, 首都医科大学, 北京同仁医院, 副主任医师

2013-05至今, 首都医科大学, 北京同仁医院, 硕士生导师

2013-05至2020-09, 首都医科大学, 北京同仁医院, 副教授

2013-08至2020-12 北京同仁医院, 眼科中心, 眼角膜科副主任

2016-11至今, 首都医科大学, 北京同仁医院, 主任医师

2017-03至2017-08, 哈佛大学, 麻省眼耳医院, 高级访问学者

2017-08至2018-08, 加州大学圣迭戈分校, Shiley眼科研究所, 高级访问学者

2019-08至今, 北京同仁医院, 北京市眼科研究所, 副所长

2020-05至今, 首都医科大学, 北京同仁医院, 博士生导师

2020-10至今, 首都医科大学, 北京同仁医院, 教授

2021-12至2024-03，北京同仁医院, 眼科中心, 眼角膜科主任

2024-03至今，北京同仁医院, 眼科中心党总支书记、眼科主任

2025-02至今，首都医科大学, 眼科学院副院长

【目前承担课程】

1.基础眼科学

2.眼科学新进展

3.科研思维的培养与实践

【主要科研成果】

研究方向：

1.眼表疾病的发病机制研究及诊疗方式创新

2.自身免疫性眼病发病机制、免疫细胞在眼表微环境中的作用

3.人工角膜及眼表修复生物材料制备及性能研究

4.重度角膜及眼表疾病手术治疗新术式

主持或参与科研项目：

1.重点任务35-2024人眼波前像差测量系统项目，工信部制造业高质量发展专项，2024.01-2026.01，211.05万，子项目负责人

2.具有生物愈合功能的复合型人工角膜系列产品研发，国家重点研发计划项目—诊疗装备与生物医用材料专项，2023YFC2410400，4500万，2023-2027，主持

3.S100A8调控NLRP3炎性小体促进巨噬细胞M1型极化在干眼中的作用机制研究，国家自然科学基金项目，82371022，49万，2024年01月至 2027 年 12月，主持

4.眼表疾病和近视的流行病学、发病机制及防治策略的研究，高层次公共卫生技术人才建设项目学科带头人，60万，2023-2026，主持

5.基于大样本队列观察及多中心随机对照试验探索环境因素；红光调控和体质干预对近视防控效果的临床研究；首都卫生发展科研专项重点攻关项目，首发2022-1-1081，90万， 2022-2024，主持

6.SP/JAK/STAT通路在过敏性结膜炎相关眼表损伤中的免疫调控机制研究；国家自然科学基金面上项目，82171018；57万，2022-2025，主持

7.眼表疾病发病机制及精准诊疗策略研究，青年北京学者计划，NO.022，2020-2025，主持

8.ROCK2-STAT通路对CD4+CD25+LAP+调节性T细胞介导的角膜移植免疫耐受调控机制的研究，国家自然科学基金面上项目，81970764，55万，2020-2023，主持

9.RhoA/ROCK/PI3K通路在调节性T细胞介导角膜移植免疫耐受中调控机制研究，北京市自然科学基金面上项目，7182037，2018.01-2020.12，主持

10.GARP在调节性T细胞介导的角膜移植免疫耐受中的调控机制研究，国家自然科学基金项目面上项目，81170824，2012-01-2015-12，主持

11.抗原特异性调节性T细胞过继转移诱导高危角膜移植免疫耐受的实验研究，国家自然科学基金项目，青年项目，30801264，2009.01-2011.12，主持

12.体外活化的NKT细胞防治高危角膜移植排斥反应耐受性调节机制的研究，北京市科学技术委员会，北京科技新星计划，2007B050，2007.01-2010.01，主持

13.角膜内皮炎患者病因及临床转归研究，北京市医管局，北京市卫生系统高层次卫生技术人才培养计划，2013-3-055，2013.06-2016.06，主持

14.GTKO/CD46猪-猴异种角膜移植的实验研究，国家自然科学基金面上项目，81470608，2015.01-2018.12，第二参与人

15.抗原特异性髓系抑制细胞过继转移抗小鼠高危角膜移植排斥反应研究，国家自然科学基金面上项目，81070709，2011.01-2013.12，第三参与人

在研，主持；发表主要论文或专著:

1. Liu Z, Li Y, Bao J, Tian L, Jie Y. Investigating shared diagnostic genes and mechanisms between metabolic syndrome and dry eye disease via integratedbioinformatics analysis and in vivo validation. Exp Eye Res. 2025 Apr23;256:110374. doi: 10.1016/j.exer.2025.110374. Epub ahead of print. PMID:40280534.
2. Liu Z, Li Y, Bao J, Li S, Wen Y, Zhang P, Feng J, Wang Y, Tian L, Jie Y.Astaxanthin ameliorates benzalkonium chloride-induced dry eye disease throughsuppressing inflammation and oxidative stress via Keap1-Nrf2/HO-1 signalingpathways. Animal Model Exp Med. 2025 Mar 5. doi: 10.1002/ame2.70000. Epub aheadof print. PMID: 40045550.
3. Wang J, Kang H, Huang X, Liu Y, He Y, Jie Y. Identification of microplasticsin human tear fluid and meibum: Implications for dry eye disease pathogenesis. JHazard Mater. 2025 Jun 5;489:137635. doi: 10.1016/j.jhazmat.2025.137635. Epub2025 Feb 18. PMID: 40015041.
4. Wang Y, Yuan J, Wen Y, Li S, Tian L, Jie Y. Clinical observation of esculinand digitalisglycosides eye drops with 0.3% sodium hyaluronate eye drops for dryeye disease: a randomized controlled trial. Sci Rep. 2025 Feb 17;15(1):5747.doi: 10.1038/s41598-025-90074-4. PMID: 39962158; PMCID: PMC11833043.
5. Yang K, Zhou J, Wang Y, Piao Y, Li M, Cheng Y, Chen X, Jie Y. Insularinfraorbital neurovascular pedicle labial salivary gland transplantation for thetreatment of severe dry eye disease: an IDEAL stage 0, 1 and 2a study. BMJ SurgInterv Health Technol. 2025 Jan 7;7(1):e000324. doi: 10.1136/bmjsit-2024-000324.PMID: 39850739; PMCID: PMC11751987.
6. Luo S, Li J, Yang Y, Jiang Y, Jie Y, Ge W. Spatial transcriptomics andsingle-cell RNA-sequencing revealed dendritic cell-mediated inflammation inkeratoconus. Ocul Surf. 2025 Apr;36:134-150. doi: 10.1016/j.jtos.2025.01.008.Epub 2025 Jan 19. PMID: 39837422.
7. Zuo ED, Zhou J, Lu H, Li Y, Wang YH, Jin YG, Jie Y, Chen XH. InsularInfraorbital Neurovascular Pedicle Labial Salivary Gland Transplantation forSevere Dry Eye: Anatomy Study and Case Report. Ophthalmic Plast Reconstr Surg.2025 Mar-Apr 01;41(2):225-231. doi: 10.1097/IOP.0000000000002803. Epub 2024 Dec10. PMID: 39656060.
8. Ren ZK, Feng J, Tian L, Wang KN, Wang JY, Shu YC, Hao YR, Jie Y, Zhou GQ. Atopological-aware automatic grading model corneal epithelial damage evaluationfrom full Corneal Fluorescence Staining images. Comput Biol Med. 2025Jan;184:109451. doi: 10.1016/j.compbiomed.2024.109451. Epub 2024 Nov 29. PMID:39615232.
9. Qin X, Hu B, Guo L, Zhang H, Li L, Jie Y, Tian L. Influence of DextranSolution and Corneal Collagen Crosslinking on Corneal Biomechanical ParametersEvaluated by Corvis ST In Vitro. Bioengineering (Basel). 2024 Nov17;11(11):1156. doi: 10.3390/bioengineering11111156. PMID: 39593816; PMCID:PMC11592382.
10. Li L, Peng Y, Lv L, Li N, Dai H, Yan C, Jin T, Luo F, Wang W, Li S, Jie Y,Pan Z. Changing indications for and trends of keratoplasty in a tertiarycomprehensive hospital in northern part of China from 2002 to 2021: a 20-yearreview. BMC Ophthalmol. 2024 Oct 17;24(1):456. doi: 10.1186/s12886-024-03708-y.PMID: 39420292; PMCID: PMC11488080.
11. Zhang X, Chen G, He Y, Tang Q, Yin Y, Jie Y. BMAL1 deficiency provokes drymouth and eyes by down-regulating ITPR2/3. Ocul Surf. 2024 Oct;34:430-440. doi:10.1016/j.jtos.2024.09.008. Epub 2024 Sep 27. PMID: 39343166.
12. Yu J, Guo Y, Tian L, Qiu L, Chen X, Cao K, Zhu L, Jie Y. Investigation oftraditional Chinese medicine constitution in individuals afflicted by dry eyedisease: A retrospective study. Medicine (Baltimore). 2024 Sep20;103(38):e39675. doi: 10.1097/MD.0000000000039675. PMID: 39312352; PMCID:PMC11419540.
13. Guo Y, Guo LL, Yang W, Tian L, Jie Y. Age-related analysis of cornealbiomechanical parameters in healthy Chinese individuals. Sci Rep. 2024 Sep17;14(1):21713. doi: 10.1038/s41598-024-72054-2. PMID: 39289420; PMCID:PMC11408652.
14. Zhao G, Wang J, Ma Q, Hao Y, Tian L, Jie Y. Comparison of upper eyelidpressure and ocular surface parameters in dry eye disease and benign essentialBlepharospasm: A cross-sectional study. Cont Lens Anterior Eye. 2024Dec;47(6):102298. doi: 10.1016/j.clae.2024.102298. Epub 2024 Sep 14. PMID:39277528.
15. Yu L, Meng Q, Li M, Tian L, Wu X, Jie Y. Heating-driven self-assembledglycyrrhizin nanomicelles loading bisdemethoxycurcumin: Preparation,characterization, and efficacy evaluation on experimental dry eye. Colloids SurfB Biointerfaces. 2025 Jan;245:114206. doi: 10.1016/j.colsurfb.2024.114206. Epub2024 Sep 7. PMID: 39255746.
16. Zhang X, Jie Y. Importance of Circadian Rhythms in the Ocular Surface.Biomolecules. 2024 Jul 4;14(7):796. doi: 10.3390/biom14070796. PMID: 39062510;PMCID: PMC11274730.
17. Lyu YY, Wang S, Chen XN, Wang ZY, Huang SS, Yuan Y, Lu HS, Yang WL, Qiao LY,Tian L, Jie Y. Ocular surface in patients with different degrees of myopia. IntJ Ophthalmol. 2024 Jul 18;17(7):1313-1321. doi: 10.18240/ijo.2024.07.17. PMID:39026912; PMCID: PMC11246949.
18. Li S, Liu Z, Deng S, Zhang Y, Jie Y. The ROCK inhibitor netarsudil in thetreatment of corneal endothelial decompensation caused by corneal endotheliitis:A case report and literature review. Int Immunopharmacol. 2024 Jul30;136:112195. doi: 10.1016/j.intimp.2024.112195. Epub 2024 May 30. PMID:38820965.
19. Li Y, Tian L, Li S, Chen X, Lei F, Bao J, Wu Q, Wen Y, Jie Y. Disruptedmitochondrial transcription factor A expression promotes mitochondrialdysfunction and enhances ocular surface inflammation by activating the absent inmelanoma 2 inflammasome. Free Radic Biol Med. 2024 Sep;222:106-121. doi:10.1016/j.freeradbiomed.2024.05.032. Epub 2024 May 24. PMID: 38797339.
20. Ruan F, Kong WJ, Fan Q, Dong HW, Zhang W, Wei WB, Jie Y. Evaluation of dryeye disease symptomatology and mental health status among patients withdifferent COVID-19 statuses. Int J Ophthalmol. 2024 May 18;17(5):822-830. doi:10.18240/ijo.2024.05.05. PMID: 38766352; PMCID: PMC11074193.
21. Cao K, Tian L, Ma DL, Zhao SQ, Li A, Jin ZB, Jie Y. Daily Low-Level RedLight for Spherical Equivalent Error and Axial Length in Children With Myopia: ARandomized Clinical Trial. JAMA Ophthalmol. 2024 Jun 1;142(6):560-567. doi:10.1001/jamaophthalmol.2024.0801. PMID: 38662345; PMCID: PMC11046409.
22. Wang Z, Song X, Wei Y, Wu X, Jie Y. Cytisine eye drops for benzalkoniumchloride-induced dry eye: safety and efficacy evaluation. Pharm Dev Technol.2024 Jun;29(5):457-467. doi: 10.1080/10837450.2024.2345148. Epub 2024 Apr 22.PMID: 38629738.
23. Gu Y, Cao K, Li A, Wang J, Guo Y, Hao Y, Tian L, Jie Y. Association betweensleep quality and dry eye disease: a literature review and meta-analysis. BMC Ophthalmol. 2024 Apr 5;24(1):152. doi: 10.1186/s12886-024-03416-7. PMID:38581010; PMCID: PMC10996221.
24. Li S, Lei G, Liu Y, Tian L, Jie Y, Wang G. The protective effect of vitaminA palmitate eye gel on the ocular surface during general anaesthesia surgery: arandomized controlled trial. Int Ophthalmol. 2024 Apr 4;44(1):168. doi:10.1007/s10792-024-03074-0. PMID: 38573375; PMCID: PMC10995056.
25. Tian L, Guo Y, Wang S, Li Z, Wang N, Jie Y. Efficacy of far infraredfunctional glasses in the treatment of meibomian gland dysfunction-related dryeye. MedComm (2020). 2024 Mar 22;5(4):e507. doi: 10.1002/mco2.507. PMID:38525107; PMCID: PMC10959456.
26. Tian L, Jin X, Wang J, Xu Y, Lu C, Zhao S, Zhu Q, Dai H, Gu H, Zhang M, WangL, Lu X, Ma L, Zhu L, Zeng Q, Zhang H, Fu Y, Li S, Tao L, Ren Q, Ding F, ZhangS, Zhu S, Li Z, Jie Y. Varenicline solution nasal spray for dry eye disease inChinese patients: a randomized phase 3 trial. Lancet Reg Health West Pac. 2024Feb 27;45:101032. doi: 10.1016/j.lanwpc.2024.101032. PMID: 38440130; PMCID:PMC10909742.
27. Li S, Zhang P, Li A, Bao J, Pan Z, Jie Y. Rho-kinase inhibitor alleviatesCD4⁺T cell mediated corneal graft rejection by modulating its STAT3and STAT5 activation. Exp Eye Res. 2024 Mar 11;242:109857. doi:10.1016/j.exer.2024.109857. Epub ahead of print. PMID: 38479724.
28. Peng R, Jie Y, Long Q, Gong L, Zhu L, Zhong X, Zhao S, Yan X, Gu H, Wu H, LiG, Zhang K, Krösser S, Xu R, Hong J. Water-Free Cyclosporine Ophthalmic Solutionvs Vehicle for Dry Eye Disease: A Randomized Clinical Trial. JAMA Ophthalmol.2024 Mar 7:e240101. doi: 10.1001/jamaophthalmol.2024.0101. Epub ahead of print.PMID: 38451509; PMCID: PMC10921345.
29. Ruan F, Fan Q, Kong W, Zhang W, Dong H, Wei W, Jie Y. Evaluation of tear filmin patients with AIDS without opportunistic ocular infections in the era ofCOVID-19: A case-control study. Indian J Ophthalmol. 2024 Feb 5. doi:10.4103/IJO.IJO_1636_23. Epub ahead of print. PMID: 38317305.
30. Zhang YH, Feng J, Yi CY, Deng XY, Zhou YJ, Tian L, Jie Y. Dynamic tearmeniscus parameters in complete blinking: insights into dry eye assessment. IntJ Ophthalmol. 2023 Dec 18;16(12):1911-1918. doi: 10.18240/ijo.2023.12.01. PMID:38111923; PMCID: PMC10700063.
31. Hao Y, Jin T, Zhu L, Zhao M, Wang S, Li Z, Tian L, Jie Y. Validation of thephenol red thread test in a Chinese population. BMC Ophthalmol. 2023 Dec7;23(1):498. doi: 10.1186/s12886-023-03250-3. PMID: 38062441; PMCID:PMC10701964.
32. Feng J, Ren ZK, Wang KN, Guo H, Hao YR, Shu YC, Tian L, Zhou GQ, Jie Y. AnAutomated Grading System Based on Topological Features for the Evaluation ofCorneal Fluorescein Staining in Dry Eye Disease. Diagnostics (Basel). 2023 Nov26;13(23):3533. doi: 10.3390/diagnostics13233533. PMID: 38066774; PMCID:PMC10706204.
33. Yang K, Wen Y, Zhu L, Bao JY, Li S, Wang YH, Feng J, Tian L, Jie Y. TheEffect of Intense Pulsed Light Treatment for Chronic Hordeolum. Biomed EnvironSci. 2023 Nov 20;36(11):1005-1014. doi: 10.3967/bes2023.131. PMID: 38098321.
34. Kang H, Feng J, Peng Y, Liu Y, Yang Y, Wu Y, Huang J, Jie Y, Chen B, He Y.Human mesenchymal stem cells derived from adipose tissue showed a more robusteffect than those from the umbilical cord in promoting corneal graft survival bysuppressing lymphangiogenesis. Stem Cell Res Ther. 2023 Nov 14;14(1):328. doi:10.1186/s13287-023-03559-2. PMID: 37957770; PMCID: PMC10644560.
35. Feng H, Li S, Jie Y. Leucocytoclastic Vasculitis Presenting as BilateralUlcerative Keratitis: A Case Report. Clin Med Insights Case Rep. 2023 Oct6;16:11795476231204358. doi: 10.1177/11795476231204358. PMID: 37808226; PMCID:PMC10559690.
36. Li S, Li A, Ruan F, Zhang W, Chen J, Huang C, Jie Y. Evaluation of theClinical Characteristics of Dry Eye Secondary to Different Types of LiverDiseases. Ophthalmol Ther. 2023 Oct;12(5):2493-2503. doi:10.1007/s40123-023-00747-4. Epub 2023 Jun 23. PMID: 37351838; PMCID:PMC10442014.
37. Tian L, Cao K, Ma DL, Lu LX, Zhao SQ, Li A, Chen CX, Ma ZF, Jin ZB, Ma CR,Jie Y. Six-month repeated irradiation of 650 nm low-level red light reduces therisk of myopia in children: a randomized controlled trial. Int Ophthalmol. 2023Oct;43(10):3549-3558. doi: 10.1007/s10792-023-02762-7. Epub 2023 Jun 15. PMID:37318667.
38. Shao Y, Jie Y, Liu ZG; Expert Workgroup of Guidelines for the application ofartificial intelligence in the diagnosis of anterior segment diseases (2023);Ophthalmic Imaging and Intelligent Medicine Branch of Chinese Medicine EducationAssociation; Ophthalmology Committee of International Association ofTranslational Medicine; Chinese Ophthalmic Imaging Study Groups. Guidelines forthe application of artificial intelligence in the diagnosis of anterior segmentdiseases (2023). Int J Ophthalmol. 2023 Sep 18;16(9):1373-1385. doi:10.18240/ijo.2023.09.03. PMID: 37724278; PMCID: PMC10475626.
39. Sun C, Tian L, Wei Y, Chen P, Wu X, Jie Y. Novelbisdemethoxycurcumin@phytomicelle ophthalmic solution: In vitro formulationappraisal and in vivo prompting rapid corneal wound healing evaluations. Exp EyeRes. 2023 Sep;234:109608. doi: 10.1016/j.exer.2023.109608. Epub 2023 Jul 28.PMID: 37517540.
40. Xiao K, Jie Y, Luo M, Long Q. Cytological and functional effect of complement3a on Human Scleral Fibroblasts. Cutan Ocul Toxicol. 2023 Sep;42(3):137-143.doi: 10.1080/15569527.2023.2226711. Epub 2023 Jun 28. PMID: 37335830.
41. Feng J, Wang J, Wu B, Shao Q, Zang Y, Cao K, Tian L, Jie Y. Association ofmeibomian gland morphology with orifice plugging and lid margin thickening inmeibomian gland dysfunction patients. Int Ophthalmol. 2023 May 4. doi:10.1007/s10792-023-02721-2. Epub ahead of print. PMID: 37140834.
42. Wu Q, Xie M, Li S, Li S, Tian L, Jie Y. Mapping the research on Sjögren'ssyndrome-related dry eye disease: a bibliometric network analysis of the past 20 years. Int Ophthalmol. 2023 May 3. doi: 10.1007/s10792-023-02711-4. Epubahead of print. PMID: 37133578.
43. Wang J, Cao K, Li S, Su B, Jin Z, Pan Z, Tian L, Shi W, Jie Y. Epidemiologiccharacteristics and the change of surgical methods of pterygium andpseudopterygium from 2013 to 2019 in China: A retrospective analysis. Heliyon.2023 Mar 30;9(4):e15046. doi: 10.1016/j.heliyon.2023.e15046. PMID: 37082637;PMCID: PMC10112034.
44. Bao J, Zhang P, Wu B, Wang J, Li S, Li A, Jie Y. Gp130 Promotes Inflammationvia the STAT3/JAK2 Pathway in Allergic Conjunctivitis. Invest Ophthalmol VisSci. 2023 Apr 3;64(4):5. doi: 10.1167/iovs.64.4.5. PMID: 37022703; PMCID:PMC10082384.
45. Tian L, Gao Z, Zhu L, Shi X, Zhao S, Gu H, Xu G, Wang L, Dai H, Zhang H, JinX, Ma K, Xu Y, Ma L, Pei C, Ke B, Krösser S, Zhang Y, Jie Y.Perfluorohexyloctane Eye Drops for Dry Eye Disease Associated With MeibomianGland Dysfunction in Chinese Patients: A Randomized Clinical Trial. JAMAOphthalmol. 2023 Apr 1;141(4):385-392. doi: 10.1001/jamaophthalmol.2023.0270.PMID: 36929413; PMCID: PMC10020931.
46. Tian L, Zhang H, Guo LL, Qin X, Zhang D, Li L, Wu Y, Jie Y, Zhang H.Corrigendum: Distribution of corneal geometric landmarks and relationshipbetween their distances and biomechanical parameters in the development ofkeratoconus. Front Bioeng Biotechnol. 2023 Jan 10;10:1104956. doi:10.3389/fbioe.2022.1104956. Erratum for: Front Bioeng Biotechnol. 2021 Dec22;9:766163. PMID: 36704309; PMCID: PMC9871052.

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