【基本情况】

牛小伟，副主任医师，心内科，专业型、学术型硕士研究生导师。

【学习经历】

2007.08—2012.06   兰州大学第一临床医学院   学士

2012.09—2015.06   兰州大学第一临床医学院   硕士

2016.09—2019.12   兰州大学第一临床医学院   博士

【工作经历】

2025.02—至今      兰州大学第一医院      副主任医师

2020.08—2025.01   兰州大学第一医院       主治医师

【主要科研成果】

研究方向：心血管疾病

主持或参与科研项目：

1.主持并完成国家自然科学基金青年项目1项

2.主持甘肃省杰出青年基金项目1项、甘肃省省级人才项目1项

3.主持市厅级项目3项

发表主要论文或专著：

1.     Xiaowei Niu, Jingjing Zhang, Shuwen Hu, Wenhui Dang, Kaiwen Wang, Ming Bai. lncRNA Oip5-as1 inhibits excessive mitochondrial fission in myocardial ischemia/reperfusion injury by modulating DRP1 phosphorylation. Cell Mol Biol Lett. 2024;29(1):72.

2.     Xiaowei Niu, Jing Zhang, Jingjing Zhang, Lu Bai, Shuwen Hu, Zheng Zhang, Ming Bai. Lipid nanoparticle-mediated Oip5-as1 delivery preserves mitochondrial function in myocardial ischemia/reperfusion injury by inhibiting the p53 pathway. ACS Appl Mater Interfaces. 2024;16(45):61565-61582.

3.     Ming Bai, Jingjing Zhang, De Chen, Mengying Lu, Junfen Li, Zheng Zhang, Xiaowei Niu. Insights into research on myocardial ischemia/reperfusion injury from 2012 to 2021: a bibliometric analysis. Eur J Med Res;2023;28(1):17.

4.     Xiaowei Niu, Wen Jun Zhang, Fei Zhao, Jingjing Zhang, Shuwen Hu, Xue Bai, Zheng Zhang, Ming Bai. Angelica sinensis Polysaccharide Suppresses Pyroptosis in Myocardial Ischemia/Reperfusion Injury via the FN1/NF-κB/NLRP3 Pathway. Nat Prod Commun. 2024;19(9):1-19.

5.     Shuwen Hu, Jingjing Zhang, Ming Bai, Xiaowei Niu. MiR-878 aggravates hypoxia/reoxygenation injury in H9c2 cardiomyocytes by inducing Pim1-mediated mitochondrial fission. Prog Biochem Biophys.2024,51(4):912-923

6.     Xiaowei Niu, Shuangshuang Pu, Chun Ling, Jizhe Xu, Jing Wang, Shaobo Sun, Yali Yao, Zheng Zhang. lncRNA Oip5-as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR-29a to activate the SIRT1/AMPK/PGC1α pathway. Cell Prolif. 2020, 53(6):e12818.

7.     Xiaowei Niu, Jingjing Zhang, Jinrong Ni, Runqing Wang, Weiqiang Zhang, Shaobo Sun, Yu Peng, Ming Bai, Zheng Zhang. Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction. Biosci Rep. 2018, 38(6): BSR20180519.

8.     Xiaowei Niu, Guoyong Liu, LichaoHuo, Jingjing Zhang, Ming Bai, Yu Peng, Zheng Zhang. Risk stratification based on components of the complete blood count in patients with acute coronary syndrome: A classification and regression tree analysis. Sci Rep. 2018, 8(1): 2838.

9.     Xiaowei Niu, Jingjing Zhang, Lanlan Zhang, Yangfan Hou, Shuangshuang Pu, Aiai Chu, Ming Bai, Zheng Zhang. Weighted gene co-expression network analysis identifies critical genes in the development of heart failure after acute myocardial infarction. Front Genet. 2019, 10:1214.

10.  Xiaowei Niu, Jingjing Zhang, Ming Bai, Yu Peng, Shaobo Sun, Zheng Zhang. Effect of intracoronary agents on the no-reflow phenomenon during primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction: a network meta-analysis. BMC Cardiovasc Disord. 2018, 18(1): 3.

【获奖情况】

获得甘肃省皇甫谧中医药科技二等奖。

【联系方式】

E-mail：ldyy_niuxw@lzu.edu.cn